The rapid advancements in health care can make it difficult for general physicians and specialists alike to keep their knowledge up to date. In medicine today, there are deficiencies in the application of knowledge translation (KT) in clinical practice. KT tools and better access to medical recommendations can lead to improvements in physicians’ decision-making processes depending on the patient’s specific clinical situation. Software for the Evolution of Knowledge in MEDicine (SEKMED) is a technological solution providing access to high-quality evidence, based on just-in-time principles, in the application of medical recommendations for clinical decision-making processes recognized by community members, accreditation bodies, the recommendations from medical specialty societies made available through campaigns such as Choosing Wisely, and different standards or accreditive bodies. The main objective is to assess the usefulness of the SEKMED platform used within a real working clinical practice, specifically the Centre intégré de santé et des services sociaux de l’Outaouais in Quebec. To achieve our main objective, physicians from the Hull and Gatineau Hospitals participate in the project. The project is divided into 4 phases: (1) orientation; (2) data synthesis; (3) develop and validate the recommendations; and (4) implement, monitor, and update the recommendations. These phases will enable us to meet our specific research objectives that aim to measure the integration of recommendations in clinical practices, the value attributed by physicians to recommendations, the user’s platform experience, the educational benefits, and the organizational benefits according to stakeholders.