Obstructive Sleep Apnea (OSA) is a condition that affects 3-7% of the general population and 40% of patients with obesity. Mandibular Advancement Device (MAD) that opens the oropharyngeal airspace by pushing the lower mandible forward is designed to treat OSA. Although Continuous Positive Airway Pressures (CPAP) are the gold standard treatment, they are bulky, cause physical and social discomfort and are known to have low rates of adherence to treatment. In contrast, MADs are as effective, less bulky and cause little if any social discomfort. Hence, adherence to treatment for MADs is greater than for CPAP [1]. The aim of this project is to design, develop and evaluate a cost effective intraoral smart MAD integrating a multi sensor platform and EEG electrodes. The multi sensor platform will consist of multiple units: sensors such as pulse oximeter, accelerometer, analog front-end, power management and signal processing unit, power supply/energy harvesting unit and a wireless transmitter unit. The smart MAD will allow intraoral measurement of physiological parameters such as blood oxygen saturation, EEG signal, heart and breathing rate as well as accelerometry to detect sleep latency, onset and duration. The platform will have potential to better evaluate the effectiveness of MAD and document sleep patterns of patients wearing the MAD.